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Additionally, ex vivo experiments with human primary T lymphocytes demonstrated LEVs ability to reduce pro-inflammatory cytokines and enhance anti-inflammatory molecules, thereby confirming that LEVs overinhibit the ERK1-2/NF-B signaling pathway to exert anti-inflammatory effects both in vitro and in vitro conditions (Raimondo et al., 2022)

doi: 10.3389/fphar.2021.601626 Received 01 September 2020 Accepted 04 January 2021 Published 03 February 2021 Volume 12 - 2021 Edited by Santiago Gmez-Ruiz, Rey Juan Carlos University, Spain Reviewed by Kui Luo, Sichuan University, China Xiaowei Zeng, Sun Yat-Sen University, China Updates Copyright 2021 Gagliardi, Giuliano, Venkateswararao, Fresta, Bulotta, Awasthi and Cosco